Metastatic breast cancer constitutes one of the most complex forms of cancer, where malignant cells spread beyond the primary tumor to distant organs and tissues. Although modern oncology has achieved considerable progress, standard therapy remains ineffective in 40-60% of metastatic breast cancer patients or loses its efficacy during treatment, making the pursuit of alternative approaches critically essential.
Innovative Breast Cancer Immunotherapy Methods
At Biotherapy International, we utilize experimental immunotherapy for breast cancer methods. Our personalized protocols target patients requiring solutions beyond conventional medical practice.
Our stage 4 breast cancer treatment and stage 3 breast cancer program combines multiple innovative immunotherapy methods that work synergistically against treatment-resistant forms of the disease. All protocols are based on extensive research and clinical experience accumulated over several decades of practice.
This approach is applied comprehensively for various complex cases, including cases of breast cancer recurrence after standard treatment. For patients with triple-negative breast cancer, we offer specialized protocols tailored to this aggressive subtype.
14-Day Oncolytic Virus Therapy Protocol for Advanced Metastatic Breast Cancer Treatment
Oncolytic viral therapy constitutes the cornerstone of our immunotherapy for breast cancer approach. Typically, this method is employed as first-line therapy to achieve substantial tumor size reduction, ideally reaching Minimal Residual Disease (MRD) status. Our specialized 14-day intensive protocol is carried out in partner clinics authorized to perform this innovative treatment.
How Our Oncolytic Virus Protocol Works
Our oncolytic viruses selectively infect and destroy breast cancer cells while sparing healthy tissue. This process:
- Directly kills cancer cells through viral replication
- Releases tumor antigens that “teach” the immune system to recognize the cancer
- Transforms non-immunogenic (“cold”) tumors into immunogenic (“hot”) ones
- Creates an inflammatory environment that enhances subsequent immunotherapies
Unlike conventional breast cancer treatment approaches, our 14-day protocol ensures maximum tumor exposure and immune system activation. This approach may be combined with direct intratumoral injection and photodynamic therapy (PDT) for enhanced effectiveness.
Checkpoint Inhibitor Therapy for Breast Cancer Immunotherapy Options
Following oncolytic virus treatment, we implement a precisely timed checkpoint inhibitor protocol as part of our comprehensive breast cancer immunotherapy approach, typically beginning 2-3 weeks after virus therapy. This timing is critical, as the immune system is now actively responsive to cancer cells that have been “tagged” by the virus.
Our Low-Dose Checkpoint Inhibitor Approach
Biotherapy International utilizes a specialized low-dose checkpoint inhibitor protocol that offers:
- Effective blocking of negative immune regulators
- Enhanced recognition of virus-marked tumor cells
- Reduced side effects compared to standard dosing
- Potential for extended treatment duration due to better tolerability
For patients who may not tolerate or prefer an alternative to standard checkpoint inhibitors, we offer Cytokine-Mediated Immunotherapy (CMI), a more affordable and home-administrable approach.
This two-step immunotherapy strategy first suppresses negative immune regulators that block anti-cancer responses, then maximally activates the immune system against the tumor using targeted approaches. The immunotherapy success rate for breast cancer with this sequenced approach has shown promising results in our clinical experience with advanced cases.
Personalized Anti-Cancer Vaccines for Advanced Breast Cancer Treatment
When cryopreserved tumor tissue is available, we develop personalized anti-cancer vaccines based on the patient’s own biomaterial. Creation of an individual vaccine is also possible during planned surgical intervention, when the necessary tumor material can be obtained. This personalized approach provides:
- Development of a vaccine adapted to the patient’s unique tumor antigens
- Training the immune system to recognize and destroy remaining cancer cells
- Synergistic interaction with other immunotherapy methods
Personalized vaccines represent one of the most promising directions in breast cancer immunotherapy options, providing precise targeting of each tumor’s unique characteristics and effectively complementing our other therapeutic methods.
ATACK Therapy: Treatment with Donor Lymphocytes
Our proprietary ATACK method (Allogeneic Targeted Activated Cancer Killer cells) uses specially prepared donor lymphocytes equipped with antibodies for targeted action against cancer cells. These donor lymphocytes are intentionally different from the patient’s cells, allowing them to recognize and destroy breast cancer cells as foreign.
The ATACK method demonstrates high effectiveness compared to traditional approaches that attempt to activate the patient’s own immune system, weakened by chemotherapy and radiation therapy.
This method shows optimal results when used after significant reduction of tumor mass by other treatment methods, especially when patients achieve MRD (Minimal Residual Disease) status.
Photodynamic Therapy (PDT): Enhancing Immunotherapy for Breast Cancer Effects
As part of our approach to metastatic breast cancer therapy, we integrate photodynamic therapy (PDT) with immunotherapeutic methods. This combined treatment:
- Uses photosensitizers that selectively accumulate in cancer cells and are activated by light of a specific wavelength
- Generates reactive oxygen species that cause direct damaging effects on tumor cells
- Stimulates local inflammatory response and immune system activation
- Works synergistically with oncolytic viruses and other immunotherapy components
Photodynamic therapy functions as a method of direct tumor destruction and as an enhancer of other therapeutic approaches. Depending on the location of metastases, PDT can be applied both systemically and locally for targeted impact on accessible tumor sites, making our treatment adaptable to various clinical situations.
Is Our Advanced Breast Cancer Treatment Right for You?
Our approach to immunotherapy for breast cancer patients may be suitable for patients who:
- Have not achieved results from standard metastatic breast cancer treatment
- Are interested in new immunotherapy treatments for breast cancer
- Have tumors accessible for direct therapeutic intervention
- Have specific molecular-genetic characteristics that may respond to ATACK therapy
- Have the ability to travel abroad to receive our specialized treatment
Evaluation Process
Our comprehensive preliminary assessment of candidates for metastatic breast cancer treatment includes:
- Detailed review of prior treatment history and responses
- Analysis of imaging studies to assess disease burden and location
- Review of molecular testing (or recommendations for additional testing)
- Personal consultation with Professor Slavin via Zoom platform
- Development of a personalized treatment protocol
International Breast Cancer Treatment Access and Patient Support
How Treatment Works
Breast cancer treatment at our center typically includes these steps:
- Initial Consultation: Remote review of medical documentation and imaging results
- Treatment Planning: Development of a personalized treatment protocol
- Oncolytic Viral Therapy: 14-day inpatient course at our breast cancer immunotherapy clinic in Germany or Kazakhstan
- Subsequent Immunotherapy: Implementation of checkpoint inhibitors or cytokine-mediated therapy
- Long-term Follow-up: Continuous monitoring in both in-person and remote formats
Our approach to stage 4 breast cancer treatment involves coordination among several specialized medical centers to ensure the most comprehensive treatment possible.
International Patient Care
As a global center of excellence for breast cancer therapy, Biotherapy International is experienced in treating patients from around the world:
- Comprehensive support for international breast cancer treatment
- Assistance with medical travel arrangements
- Continued telemedicine support after patients return home
- Coordination with local oncologists for follow-up care
We understand the unique challenges faced by international patients seeking advanced cancer care and have developed systems to make the process as smooth as possible, regardless of where you’re traveling from.
Taking the Next Step
To learn whether our advanced breast cancer treatment program may be appropriate for your specific situation:
- Fill out our contact form at the bottom of this page
- Submit your medical records for review by emailing [email protected]
- Schedule a personal consultation with Professor Slavin via Zoom
Professor Slavin personally reviews each case to determine whether our experimental methods are suitable for addressing your medical situation. Many patients who come to us have already undergone standard treatment protocols without achieving remission from metastatic breast cancer and are seeking the most advanced solutions in breast cancer immunotherapy. Our program provides a unique opportunity to receive therapy that may not be available in medical institutions in your country.
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